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KMID : 0604520170430030239
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Journal of the Society of Cosmetic Scientists of Korea
2017 Volume.43 No. 3 p.239 ~ p.245
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Effect of Methoxy PEG-45 Thioctate (LA-PEG) against Oxidative Protein Damage and Anti-glycation
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Kim Jin-Hwa
Oh Jung-Young
Bae Jun-Tae
Lee Geun-Soo
Pyo Hyeong-Bae
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Abstract
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Aging is a physiological and irreversible, progressive process involving changes in the ability to maintain cellular functionality. It affects tissues, organs and the whole organism and thus finally cause to death. Oxidative stress has been postulated to contribute significantly to the accelerated accumulation of advanced glycation endproducts (AGEs) in collagen, which is implicated in the process of skin aging. In the present study, glycation inhibitory activity of methoxy PEG-45 thioctate (LA-PEG), and its inhibitory effect of cellular oxidation and senescence was investigated. Treatment of LA-PEG significantly showed lower fluorescent intensity induced by AGEs. In addition, LA-PEG was significantly reduced the formation of ROS induced by AGEs. High antioxidant and anti-glycation activities of LA-PEG in glycated collagen model indicated its contribution to anti-aging process. Cellular senescence leads to an increase in senescence-associated β-galactosidase (SA-β-gal) activity, which can be used as a biomarker to identify senescent cells. Treatment with LA-PEG showed a dose-dependent, statistically significant decreased in SA-β-gal indicating reduced senescence. These results suggest that LA-PEG may have potent anti-aging effects and can be used as new functional materials against cellular accumulation of AGEs.
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KEYWORD
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anti-glycation , advanced glycation endproducts (AGEs) , antioxidant , cellular senescence , anti-aging
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